Mechanisms of Hypoglycemia-Associated Autonomic Failure in Diabetes
نویسندگان
چکیده
منابع مشابه
Mechanisms of hypoglycemia-associated autonomic failure in diabetes.
Copyright © 2013 Massachusetts Medical Society. Iatrogenic hypoglycemia is the limiting factor in the glycemic management of diabetes.1 It causes recurrent illness in most people with type 1 diabetes mellitus and in many with advanced type 2 diabetes mellitus and is sometimes fatal. It generally precludes maintenance of euglycemia over a lifetime of diabetes and thus full realization of the ben...
متن کاملHypoglycemia-associated autonomic failure in diabetes.
Hypoglycemia is the limiting factor in the glycemic management of diabetes. The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent antecedent iatrogenic hypoglycemia causes both defective glucose counterregulation (by reducing the epinephrine response to falling glucose levels in the setting of an absent glucagon response) and hypoglycemia unawareness (by...
متن کاملDiverse causes of hypoglycemia-associated autonomic failure in diabetes.
N Engl J Med 2004;350:2272-9. Copyright © 2004 Massachusetts Medical Society. atrogenic hypoglycemia is the limiting factor in the glycemic management of diabetes. 1,2 It causes recurrent symptomatic and sometimes, at least temporarily, disabling episodes in most people with type 1 diabetes as well as in many with advanced type 2 diabetes, and is sometimes fatal. Furthermore, iatrogenic hypogly...
متن کاملHypoglycemia-associated autonomic failure in advanced type 2 diabetes.
We tested the hypotheses that the glucagon response to hypoglycemia is reduced in patients who are approaching the insulin-deficient end of the spectrum of type 2 diabetes and that recent antecedent hypoglycemia shifts the glycemic thresholds for autonomic (including adrenomedullary epinephrine) and symptomatic responses to hypoglycemia to lower plasma glucose concentrations in type 2 diabetes....
متن کاملExercise-Related Hypoglycemia-Associated Autonomic Failure in Diabetes
Iatrogenic hypoglycemia is the limiting factor in the glycemic management of diabetes (1,2). It causes recurrent morbidity in most people with type 1 diabetes as well as many with advanced type 2 diabetes and is sometimes fatal. It precludes maintenance of euglycemia over a lifetime of diabetes and, therefore, full realization of the benefits of glycemic control. It compromises physiological an...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2013
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmra1215228